Friday, July 09, 2010

The University of North Carolina at Charlotte


Project TitleAdenoma and Colorectal Cancer Detection Methods and Kits
Track CodeP2011-041
Short Description

Adenoma and colorectal cancers detected through screening bacteria populations of the colon


Colorectal cancer (CRC) is the second leading cause of cancer death for men and women in the United States. More than 95% of colorectal cancer cases are adenocarcinomas.  The CDC reported that 136,717 people in the United States were diagnosed with colorectal cancer in 2009.                                 

The microbiota is an overlooked factor in CRC. Using more sensitive techniques, we provide an in depth assessment of the mucosal microbiota that suggests that microbial signatures are associated with adenomas and precursors to CRC. In particular, microbial richness and diversity strongly distinguished individuals with adenomas from controls. Importantly, we identified that adenoma subjects had higher abundance of certain potentially pathogenic bacteria.                                                                                      

 Advantages and Applications:                                                              

  • Non-invasive commercial potential for identifying people at risk;              
  • Lead to the development of preventive, prognostic, and therapeutic microbial tools for CRC;                                                                       
  • Could be used to modify people’s diet to restore balance in the gut microbiota and to prevent adenomas;                                                       
  • Knowledge of the mucosal microbial signature has potential use in predicting development of future adenomas.                                            

Patent Pending: PCT/US2012/41020                                                         

Contact:  Bradley Fach, Associate Director  704-687-8018 or

Tagscolon, cancer, Adenoma, diagnostic, bacteria, microbiota, colorectal, microbial
Posted DateOct 7, 2013 2:44 PM

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